商品介绍
PRAS40 (phospho-Ser183) rabbit pAb
- Catalog No.：YP1449
- Applications：WB
- Reactivity：Human,Mouse
- Data Sheet
- MSDS
- Support
- Description
- References ( 0 )
- Protocol
- Gene Name：
- AKT1S1 PRAS40
- Protein Name：
- PRAS40 (Ser183)
- Human Gene Id：
- 84335
- Human Swiss Prot No：
- Q96B36
- Mouse Gene Id：
- 67605
- Mouse Swiss Prot No：
- Q9D1F4
- Immunogen：
- Synthesized phosho peptide around human PRAS40 (Ser183)
- Specificity：
- This antibody detects endogenous levels ofHuman Mouse PRAS40 (phospho-Ser183)
- Formulation：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source：
- Rabbit
- Dilution：
- WB 1:1000-2000
- Purification：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration：
- 1 mg/ml
- Storage Stability：
- -20°C/1 year
- Other Name：
- Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
- Observed Band(KD)：
- 40
- Background：
- AKT1 substrate 1(AKT1S1)Homo sapiensAKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008],
- Function：
- function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,
- Subcellular Location：
- nucleoplasm,cytoplasm,cytosol,TORC1 complex,protein complex,
- Expression：
- Brain,Epithelium,Eye,Skin,
- June 19-2018
- WESTERN IMMUNOBLOTTING PROTOCOL
- June 19-2018
- IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL
- June 19-2018
- IMMUNOFLUORESCENCE PROTOCOL
- June 19-2018
- FLOW CYTOMEYRT PROTOCOL
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN
- July 13-2018
- CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN
- July 13-2018
- CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN
- July 13-2018
- Antibody-FAQs
品牌介绍
Immunoway是一家刚成立不就的美国公司，公司位于美国德克萨斯州。主要致力于免疫途径生物技术，开发高质量的ELISA试剂盒、代谢分析试剂盒、与癌症、凋亡、细胞生长和信号转导有关的抗体和抗体/蛋白微阵列方面一直处于领先地位。公司目标是帮助世界各地的生命科学研究人员简化和加速他们的研究与更好的产品和服务。
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