• Gene Name：
• HSD17B11

• Protein Name：
• Estradiol 17-beta-dehydrogenase 11

• Human Gene Id：
• 51170

• Human Swiss Prot No：
• Q8NBQ5

• Mouse Swiss Prot No：
• Q9EQ06

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DHRS8. AA range:71-120

• Specificity：
• 17β-HSD11 Polyclonal Antibody detects endogenous levels of 17β-HSD11 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Rabbit

• Dilution：
• Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -20°C/1 year

• Other Name：
• HSD17B11; DHRS8; PAN1B; PSEC0029; Estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lym

• MolecularWeight(Da)：
• 32964

• Observed Band(KD)：
• 36

• Background：
• hydroxysteroid 17-beta dehydrogenase 11(HSD17B11) Homo sapiensShort-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009],

• Function：
• catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,function:Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.,tissue specificity:Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated ep

• Subcellular Location：
• extracellular region,cytoplasm,lipid particle,cytosol,intracellular membrane-bounded organelle,

• Expression：
• Bone marrow,Colon,Kidney,Liver,Lymphoma,Retina,Urinary blad

Cui, Jiaqi, et al. "MicroRNA‑143 increases cell apoptosis in myelodysplastic syndrome through the Fas/FasL pathway both in vitro and in vivo." International journal of oncology 53.5 (2018): 2191-2199.

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
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• June 19-2018
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• July 13-2018
• Antibody-FAQs