Synthesized phosho peptide around human Rictor (Thr1135)
Specificity:
This antibody detects endogenous levels ofHuman Mouse Rictor (phospho-Thr1135)
Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:
Rabbit
Dilution:
WB 1:1000-2000
Purification:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:
1 mg/ml
Storage Stability:
-20°C/1 year
Other Name:
Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
Observed Band(KD):
190
Background:
RPTOR independent companion of MTOR complex 2(RICTOR) Homo sapiensRICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],
Function:
function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 "Ser-473" phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,